Veno-occlusive Disease of the Liver and Indian Childhood Cirrhosis

Veno-occlusive disease of the liver and Indian childhood cirrhosis.

Cirrhosis of the liver is rare in childhood in the temperate zone and it is then usually due to some specific and traceable cause, such as Rhesus incompatibility, galactosaemia, congenital syphilis, in association with congenital abnormalities of the biliary apparatus, or following infective hepatitis. In most of the subtropics and tropics-at least according to present probably incomplete evide...

The veno-occlusive disease of the liver.

BACKGROUND AND OBJECTIVE The veno-occlusive disease of the liver (VOD) is a disorder caused by the non-thrombotic occlusion of the central veins of hepatic lobules. The clinical features are similar to those of intrahepatic portal hypertension (unexplained weight gain, ascites, painful hepatomegaly, jaundice). In the past, this disease was rather infrequent and was linked to the absorption of t...

Haemodynamic studies in veno-occlusive disease of the liver.

Haemodynamic studies in 8 tribal patients from central India with veno-occlusive disease of the liver are reported. The disease was caused by eating cereals contaminated with seeds of a crotalaria species rich in toxic pyrrolizidine alkaloids similar to monocrotaline and fulvine. All patients showed raised hepatic venous wedge pressures and pressure gradients between hepatic venous wedge and fr...

Pulmonary veno-occlusive disease.

Veno-occlusive disease of the liver in renal transplant patients.

Veno-occlusive disease (VOD) of the liver is characterized by histological findings which include fibrous obliteration of the small hepatic veins by connective tissue and centrilobular necrosis [1]. VOD is a classic complication of chemo-irradiation therapy prior to bone marrow transplantation [2] and is also thought to be related to azathioprine therapy after kidney transplantation [3]. VOD is...